Everything You Should Know About How CBD Interacts with Drugs

CBD Interacts with Drugs
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Did you know that cannabidiol or CBD can significantly change the way your body works to process certain medicines? CBD derived from marijuana and hemp has gained global attraction for its potential to alleviate symptoms of chronic pain, insomnia, anxiety, and several other health conditions. While research and clinical trials are in progress to determine the effectiveness of CBD, many people have already started giving it a try to get a cure for their health-related problems.

According to the latest research, cannabidiol or CBD offers safe usage, but it might have some minor downsides as well. Using CBD comes with certain careful measurements, especially if you want to identify its potential to interact with several medications.

In other words, these concerns refer to the natural process of how your body processes certain substances. Therefore, it becomes necessary to talk to your physician about every prescribed medicine, vitamin, and supplement that you are already taking.

CYP450 Enzymes and Drug Metabolism

Your body needs to metabolize or break down whatever medication or substance you take. The process of drug metabolism takes place throughout your body, including the gut. Your liver, however, has to play a vital role in the entire metabolism process.

CYP450 or Cytochrome P450 – a group of Enzymes, converts foreign substances, allowing them to eliminate from the body. Some several medicines and substances can affect CYP450 in two ways. They can either slow or speed up drug metabolism. Depending on the change in metabolism rate, your body alters the way your body will process the medicines or supplements.

As mentioned earlier, a group of CYP450 enzymes metabolizes many cannabinoids, such as CBD. Its CYP 34A also participates in the task, though cannabidiol interferes with CYP3A4 during this process. The CYP3A4 enzyme metabolizes about 60% of clinically prescribed drugs.

However, if CBD inhibits CYP3A4, it cannot effectively break down medicines in your body. In some cases, the reverse can take place as well. Some medications slow down CYP34A, and if you use CBD while using those drugs, your body won’t be able to process cannabidiol as well.

Using CBD with Other Medications

People interested in trying cannabidiol as an added therapy to alleviate symptoms of a specific medical condition should talk to their physician about it first. Healthcare providers can help you determine the right CBD product, its suitable dosage for your particular medical disorder, dosage, and time, which goes safe with your prescribed drugs.

In some situations, your doctor might need to monitor the blood plasma level of the medications given for your specific condition. At this point, make sure you do not stop any of your prescribed medicines to start CBD unless your physician gives you a green signal for it.

Substance Interactions

While several studies are in process to identify potential interaction between cannabidiol and specific drugs, defined rules are helpful for consumers. And one of which is to avoid cannabidiol if your drugs carry a grapefruit warning label, which says people must not take grapefruit or its juice while using that specific medication. People overlooking these cautions can experience a high concentration of the medicines in the bloodstream and several adverse side effects.

Almost 85 drugs interact with grapefruit and some related citrus juices, such as pomelos, tangelos, and Seville oranges. Since the chemicals found in grapefruit inhibit CYP3A4 as same as it does CBD, it could result in a slow breakdown of drugs. Many studies are in progress to determine how specific interactions take place between cannabidiol and numerous medications.

Besides several pieces of research, a few small scientific trials have also been conducted. A study of twenty-five children with hard-to-treat epilepsy took place in which thirteen children consumed both cannabidiol and clobazam. Studies found a higher level of the clobazam in these broods, which indicates that consuming CBD and clobazam simultaneously has no downsides. However, the writers recommend careful monitoring of medication levels during treatments.

Another study where almost 39 adults with 42 children consumed cannabidiol in the form of Epidiolex found CBD doses getting increased every two weeks. During the research, the monitoring of serum levels of the AEDs also took place time by time. Although the serum levels continued to be the same within the established therapeutic range for almost everyone, drugs like desmethrylclobzam and clobazam showed serum levels outside the remedial range.

According to the initial studies, cannabidiol has the potential to mess with medicine levels in your body system, even if you are following your prescribed dose. It, however, needs more research to identify if the severity of CBD interactions throughout numerous medications and to recommend taking medicines with CBD.

Side Effects

It is always advisable to use CBD under your doctor’s supervision so that you are sure to make a safe use of cannabidiol with medications. It even goes the same for those medications that come with a grapefruit warning.

Depending on your particular case, your doctor may suggest monitoring of plasma serum level of the medicines you are taking. In some cases, you might also need monitoring of your liver functioning. When it comes to using CBD with your prescribed medicines, make sure to watch for any potential changes that may occur by the use of prescribed drugs and CBD.


Always talk to your doctor if you are thinking of trying cannabidiol products. It is even more crucial if you are experiencing a health problem and using prescribed medication. Make sure you do not stop your prescription for trying CBD unless you have conversed with your doctor, and they have let you a go-ahead.

Medicine with a grapefruit warning can better interact with CBD. Even if you are using one of the said medicines, your physician will be the right person who can formulate a treatment plan for you.

Make sure to follow what your healthcare provider suggests to you because their treatment plan will work for you through close monitoring of the medication level in your body system so that you can benefit from both your prescribed medicine and CBD.

Likewise, your healthcare practitioner or a reputable pharmacist may recommend a quality cannabidiol product according to your medical requirements. You can see some very interesting details on to find reputable CBD products and get knowledge on how you can read CBD labels.

Heather Breese
Heather Breese is a qualified writer who fell in love with creativity and became a specialist creator and writer, focused on readers and market need.

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